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There is some legal dispute as to the definition of "death." This answer focuses on the anatomical definition of brain death: Death has occurred once the brain ceases to generate any neuronal activity.

The fastest mechanism of death, then, would be any injury that destroys the critical centers of the brain. The brainstem plays a significant role in maintaining consciousness and controlling cardiac and respiratory functions, so devastating injury to the brain stem could cause immediate death. Any global injury to the brain, such as diffuse axonal injury, can cause a coma or death; the most severe of these injuries can cause immediate death.

Of course, the most rapid mechanism of death would be the immediate and total destruction of the critical life tissues. For example, a large proximal explosion could immediately destroy the entire brain, thus causing instantaneous death.

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Q: What is the most rapid mechanism of death?
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