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depends on the macromolecule. the broad category would be "covalent bonds" ... but there are sort of subcategories... like, proteins are joined with peptide bonds (which occur through dehydrogenation - removal of a water molecule) protein folding is also a function of hydrogen bonding. long chain polycarbons are just covalently bound (carbon-carbon bonds) could be double or single bonds depending on degree of saturation

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