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Regardless the size of an organism, whether only a few cell layers thick or comprised of many trillions of cells like ourselves, the maximum possible size or volume of a cell is very limited. Cells depend upon the free diffusion of nutrients in and out of their cell membrane. As a cell grows larger, its level of surface area to volume decreases and it becomes more difficult to effectively transport nutrients sufficient for their size across the membrane. They are also limited by the relative strength of the cell wall or cell membrane. The greater a cell's volume, the more pressure is being exerted on the membrane and if the pressure were to become too high, the cell would burst. As a result of these physical limitations, cells of any respective tissure are generally the same size accross species.

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