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If a base is merely substituted, the reading frame remains altered only by that one base, which may or may not change the amino acid encoded in the codon. If a base were inserted or deleted, there will be a reading frame shift which would have a profound effect on the amino acids encoded.

For example, a sample of RNA has the following sequence:

AUG AUA AAG CUA CCG GGC UAG ...

which translates to M-I-K-L-P-G

If the second condon changed from AUA to AUC, then the amino acid sequence would remain the same.

If the second condon were to have its second A deleted, then the entire amino acid sequence changes to:

M-I-S-T-R-A...

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