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Glucuronyl transferase is a liver enzyme. It changes bilirubin into a form that can be removed through the bile. It also changes some hormones, medicines, and toxins into non-harmful products.
If the body does not produce enough glucuronyl transferase, jaundice can occur.
ReferencesBerk PD, Korenblat KM. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 150.
What else can I help you with?
Does phenobarbital inhibit bilirubin conjugation?
No, actually quite the opposite. Phenobarbital enhances conjugation of bilirubin in the liver by inducing microsomal enzymes, like UDP-glucuronyl transferase.
Metabolism of bilirubin in the fetus?
In the fetus, bilirubin metabolism is limited due to the immature liver and the absence of adequate glucuronyl transferase enzymes, which are necessary for bilirubin conjugation. Instead, bilirubin is primarily transported to the placenta, where it is excreted into the maternal circulation for elimination. This process helps prevent bilirubin accumulation in the fetal bloodstream, which could lead to complications like kernicterus. After birth, the newborn's liver matures, enabling effective bilirubin metabolism and conjugation.
Can jaundice be prevented?
the activity of the enzyme UDP-glucuronyl transferase is low in the newborns.so UDP- glucuronic acid for conjugation is limited. this leads to high level of unconjugated bilirubin (beyond 25mg/dl) .it may cross the blood brain barrier resulting in hyperbilirubinemic toxic encephalopathy or kernicterus . prevention aspects: the drug phenobarbital is used, as it induce bilirubin metabolising enzymes in liver. in some neonates blood transfusion may be necessaryto prevent brain damage. phototherapy is continuously carried out till the serum bilirubin becomes normal. phototheraphy deals with the exposure of the jaundiced neonates to blue light as bilirubin absorbs the blue light and get converted to non toxic lumirubin and get excreted.
What is S9 liver fraction?
Liver S9 fractions are subcellular fractions that contain drug-metabolizing enzymes including the cytochromes P450, flavin monooxygenases, and UDP glucuronyl transferases. Liver S9 fractions are a major tool for studying xenobiotic metabolism.
Can neonatal jaundice be prevented?
the activity of the enzyme UDP-glucuronyl transferase is low in the newborns.so UDP- glucuronic acid for conjugation is limited. this leads to high level of unconjugated bilirubin (beyond 25mg/dl) .it may cross the blood brain barrier resulting in hyperbilirubinemic toxic encephalopathy or kernicterus . prevention aspects: the drug phenobarbital is used, as it induce bilirubin metabolising enzymes in liver. in some neonates blood transfusion may be necessaryto prevent brain damage. phototherapy is continuously carried out till the serum bilirubin becomes normal. phototheraphy deals with the exposure of the jaundiced neonates to blue light as bilirubin absorbs the blue light and get converted to non toxic lumirubin and get excreted.
Can a cat drink soda?
Most cats will not drink any kind of juice. First of all, cats are strictly carnivores, and do not usually like to eat or drink anything but animal products (meat, eggs, dairy). Moreover, juice is too harsh, acidic, and abrasive for their heightened senses. In particular, cats really, really hate any and all citrus fruit -- lemons, limes, oranges, grapefruit -- and will physically recoil if you put a cup of orange juice up in their face to smell. There are some odd exceptions. My uncle once had a cat that loved to eat oranges. Just oranges, though, not orange juice. But most cats will not touch fruit and especially fruit juice.
