30 mins
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Depakine 500 is an immediate-release formulation of sodium valproate, while Depakine Chrono 500 is a controlled-release formulation. This means that Depakine Chrono releases the medication slowly over time, providing a more consistent blood level compared to Depakine 500, which releases the medication more rapidly. Your doctor will determine the appropriate formulation based on your specific needs.
Ethyl cellulose is commonly used in floating tablets as a hydrophobic polymer to provide controlled release of drugs by forming a barrier that slows down the penetration of water into the tablet core. This helps the tablet to float on the gastric fluids, prolonging the residence time in the stomach and improving drug absorption. Ethyl cellulose can also enhance the buoyancy of the tablet due to its low density, which aids in maintaining the tablet in the upper part of the stomach.
Putting more than one Alka Seltzer tablet in a lava lamp can cause the liquid to bubble rapidly and overflow, creating a mess. It can also potentially damage the lava lamp by putting too much pressure on the glass and heating element. It is not recommended to use more than one Alka Seltzer tablet at a time in a lava lamp.
Objects made of iron are coated with paint or a protective metal layer to prevent corrosion. Iron is susceptible to rust when exposed to moisture and oxygen, which can weaken the material over time. The coating acts as a barrier, preventing direct contact between the iron and the elements that cause corrosion.
The disintegration time of coated tablets is typically longer compared to uncoated tablets due to the additional layer of coating that needs to dissolve before the tablet can disintegrate. Coated tablets are designed to release the medication gradually over time, which can affect the disintegration process. Uncoated tablets, on the other hand, disintegrate more quickly as they do not have an additional barrier to dissolve. The specific disintegration times can vary depending on the formulation of the tablet and the conditions in which it is tested.
dissintigration time is the time that required to convert solid tablet in to granlues.
The time of disintegration is basically based by the pharmaceuticals keeping in mind the timing of the digestive system so that the medicine is administered at the correct location,throat, stomach,upper or lower intestines etc. to have the necessary effect.
30 minuts as well as 1 hr in gstric fluid
For a drug to show maximum availability in the body it must be in solution form. So as a first step, the tablets that we take in, should break down to smaller particles or granules.This breaking up process is known as disintegration. disintegration is an important parameter of the tablet. It is determined with an apparatus described
The disintegration time of uncoated tablets is typically around 15 minutes to ensure that the tablet breaks down sufficiently in the gastrointestinal tract for effective absorption of the active ingredients. This time frame allows for the tablet to dissolve into smaller particles, facilitating their dispersion in the digestive fluids. The 15-minute benchmark is a balance between ensuring rapid release and allowing adequate time for the tablet's components to dissolve without compromising the therapeutic effect. Additionally, regulatory standards often set this time as a benchmark for quality control.
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Fast dispersible tablets disintegrate either rapidly in water, to form a stabilized suspension, or disperse instantaneously in the mouth to be swallowed without the aid of water. A direct compression method was used to prepare these two types of tablets containing coated ibuprofen as a high dosed model drug. The properties of the water dispersible tablet, such as porosity, hardness, disintegration time and increase in viscosity after dispersion, were investigated. The selected tablet formulation, containing 26% galactomannan and 5% crospovidone, disintegrates before the galactomannan starts to swell. These tablets disperse in water within 40 s and show a crushing strength of 95 N. To develop an orodispersible tablet, a rotatable central composite design was applied to predict the effects of the quantitative factors mannitol and crospovidone as well as compression force on the characteristics of the tablet. Special emphasis was paid to the development of a wetting test, replacing the normal disintegration method. An optimum tablet formulation, containing 34% mannitol and 13% crospovidone, provides a short wetting time of 17 s and a sufficient crushing strength of 40 N. In conclusion, fast dispersible tablets with acceptable hardness and desirable taste could be prepared within the optimum region.
Boris Yeltson
Rust, disintegration of materials, etc. etc.
Roots cause disintegration by growing into small cracks in rocks or structures and exerting pressure as they expand, leading to physical breakup of the material. Additionally, roots can release chemicals that break down the composition of the material they are growing on, causing further disintegration over time.
red stopper/silicion coated