For a drug to show maximum availability in the body it must be in solution form. So as a first step, the tablets that we take in, should break down to smaller particles or granules.This breaking up process is known as disintegration. disintegration is an important parameter of the tablet. It is determined with an apparatus described
basic principal of dissolution run as per individuala monograph and know the % of active drugs in sample
Roots cause disintegration by growing into small cracks in rocks or structures and exerting pressure as they expand, leading to physical breakup of the material. Additionally, roots can release chemicals that break down the composition of the material they are growing on, causing further disintegration over time.
Taking 900ml of water as the disintegration medium in a disintegration test is commonly used to simulate the conditions of the stomach where the dosage form is expected to disintegrate. This volume is considered sufficient to provide the necessary agitation and dissolution properties needed for the test. It also helps ensure reproducibility and accuracy in the disintegration test results.
Each isotope has a different rate of radioactive disintegration characterized by the half-life, the time necessary to reduce by half the number of atoms.
Radioactivity is the disintegration of the substance by its own. This means disintegration depends only on one reactant concentration i.e.,on itself. So this is a first order reaction.
basic principal of dissolution run as per individuala monograph and know the % of active drugs in sample
dissintigration time is the time that required to convert solid tablet in to granlues.
Boris Yeltson
The disintegration time of coated tablets is typically longer compared to uncoated tablets due to the additional layer of coating that needs to dissolve before the tablet can disintegrate. Coated tablets are designed to release the medication gradually over time, which can affect the disintegration process. Uncoated tablets, on the other hand, disintegrate more quickly as they do not have an additional barrier to dissolve. The specific disintegration times can vary depending on the formulation of the tablet and the conditions in which it is tested.
vicats apparatus is used for initial setting time of cement.
The Disintegration Machine was created in 1929.
The Disintegration Loops was created in 1982.
Rust, disintegration of materials, etc. etc.
The disintegration time of a film-coated tablet can vary depending on the formulation and the specific film coating used. Generally, film-coated tablets are designed to disintegrate in the stomach or intestines within a few minutes to one hour after ingestion. The disintegration time is determined during the tablet development process to ensure proper drug release and absorption.
Roots cause disintegration by growing into small cracks in rocks or structures and exerting pressure as they expand, leading to physical breakup of the material. Additionally, roots can release chemicals that break down the composition of the material they are growing on, causing further disintegration over time.
The time of disintegration is basically based by the pharmaceuticals keeping in mind the timing of the digestive system so that the medicine is administered at the correct location,throat, stomach,upper or lower intestines etc. to have the necessary effect.
The disintegration constant is the fraction of the number of atoms of a radioactive nuclide which decay in unit time; is the symbol for the decay constant in the equation N = Noe^-t, where No is the initial number of atoms present, and N is the number of atoms present after some time (t).