The time of disintegration is basically based by the pharmaceuticals keeping in mind the timing of the digestive system so that the medicine is administered at the correct location,throat, stomach,upper or lower intestines etc. to have the necessary effect.
The disintegration time of coated tablets is typically longer compared to uncoated tablets due to the additional layer of coating that needs to dissolve before the tablet can disintegrate. Coated tablets are designed to release the medication gradually over time, which can affect the disintegration process. Uncoated tablets, on the other hand, disintegrate more quickly as they do not have an additional barrier to dissolve. The specific disintegration times can vary depending on the formulation of the tablet and the conditions in which it is tested.
The disintegration time of a film-coated tablet can vary depending on the formulation and the specific film coating used. Generally, film-coated tablets are designed to disintegrate in the stomach or intestines within a few minutes to one hour after ingestion. The disintegration time is determined during the tablet development process to ensure proper drug release and absorption.
The brand name Flagyl, which is non-generic Metronidazole, does offer an enteric coated option. Since I have used this medication more than on one occasion to treat giardiasis, I understand the severity of nausea that normally accompanies it's use as a side effect. While not entirely mitigating these symptoms, the enteric version does reduce them to a more tolerable level and make it more likely that patients will take their medication on time and to completion. For giardiasis, the enteric version of Flagyl should be the default prescription.
dissintigration time is the time that required to convert solid tablet in to granlues.
While an enteric aspirin can be crushed it is not recommended. Enteric coated aspirin is usually time release. Crushing time release aspirin can cause one to overdose as the aspirin is released into the system all at once.
Some, yes. Others are coated for time release or safety. Ask your doctor or pharmacist for specific information.
THERE ARE BASICALLY THREE GROUPS OF medications that should never be crushed, cut in half, or chewed: ENTERIC COATED-they are coated to disslove in the intestine, otherwise it can cause gastric irritation. TIME-RELEASE CAPSULES (also called spansules) -they are meant to be released over time, otherwise it can cause an overdose. SUSTAINED-RELEASE TABLETS- they are meant to be released over time, otherwise it can cause an overdose. Some common 2 letter abbreviations after the name of the medication to indicated time-relaease or sustained release::LA (long acting); DR (delayed release); SA (slow acting); SR (sustained release); ER (extended release).Read labels CAREFULLY.
The geltabs are tablets which are coated with a smooth gelatin coating, (supposedly) making them easier to swallow than the plain kind.
The disintegration time of uncoated tablets is typically around 15 minutes to ensure that the tablet breaks down sufficiently in the gastrointestinal tract for effective absorption of the active ingredients. This time frame allows for the tablet to dissolve into smaller particles, facilitating their dispersion in the digestive fluids. The 15-minute benchmark is a balance between ensuring rapid release and allowing adequate time for the tablet's components to dissolve without compromising the therapeutic effect. Additionally, regulatory standards often set this time as a benchmark for quality control.
For a drug to show maximum availability in the body it must be in solution form. So as a first step, the tablets that we take in, should break down to smaller particles or granules.This breaking up process is known as disintegration. disintegration is an important parameter of the tablet. It is determined with an apparatus described
Enteric coated tablet are only to make the medication easier on the stomach. The coating all comes off at about the same time in the body and the entire dose is absorbed. SR, CR, slow-release, controlled release, are manufactured to release the dose of medication slowly over usually 12 hours. They are not for the protection of the stomach but to allow once or twice a day dosing of medications. If a SR/CR is crushed or chewed before swallowing, the entire dose will be absorbed at once and could be very dangerous resulting in overdose.
EC in ferrous sulfate EC stands for "extended release" or "enteric coated." This means that the medication is formulated to release the active ingredient slowly over an extended period of time to provide a longer-lasting effect.