The pKa of NH3, also known as ammonia, is approximately 38. Ammonia is a weak base, meaning it does not completely dissociate in water to form hydroxide ions. The pKa value indicates the extent to which ammonia will accept a proton in a chemical reaction. A higher pKa value signifies a weaker acid or base.
The pKa values of Amino acids depends on its side chain. However, the protonated amine group (NH3+) tends to have a pKa greater than 8.8, whereas the carboxylic acid (COOH) tends to have a pKa of 1.8 - 2.8. If you keep your amino acid at a pH between this value, you will likely have a Zwitter ion.
This represent a buffer of a weak base (NH3) and the conjugate acid (NH4+), so one can use a form of the Henderson Hasselbalch equation like pOH = pKb + log [conj.acid][base]. The pKb for NH3 is 9.25, so pH = 9.25 + log [0.17]/[0.13] = 9.25 + 0.12 = 9.37 = pH
The pKa of: NH4(+) = 9.4 NH3 = 38 NH2(-) = EXTREMELY HIGH (due to the the instability of compounds like NH(2-) and N(3-) the pKa values are not currently known -- they really aren't around for long enough to get an accurate pka value. There may be experimental values in the literature somewhere, but they are likely not going to be the same from source to source!)
The pKa of diisopropylamine is around 10-11.
The pKa of bromoacetic acid is approximately 2.64.
effect of pka valu in an organic reaction
The pKa values of Amino acids depends on its side chain. However, the protonated amine group (NH3+) tends to have a pKa greater than 8.8, whereas the carboxylic acid (COOH) tends to have a pKa of 1.8 - 2.8. If you keep your amino acid at a pH between this value, you will likely have a Zwitter ion.
This represent a buffer of a weak base (NH3) and the conjugate acid (NH4+), so one can use a form of the Henderson Hasselbalch equation like pOH = pKb + log [conj.acid][base]. The pKb for NH3 is 9.25, so pH = 9.25 + log [0.17]/[0.13] = 9.25 + 0.12 = 9.37 = pH
The pKa of: NH4(+) = 9.4 NH3 = 38 NH2(-) = EXTREMELY HIGH (due to the the instability of compounds like NH(2-) and N(3-) the pKa values are not currently known -- they really aren't around for long enough to get an accurate pka value. There may be experimental values in the literature somewhere, but they are likely not going to be the same from source to source!)
The pKa of diisopropylamine is around 10-11.
The pKa of bromoacetic acid is approximately 2.64.
The pKa value of Doxofylline is approximately 4.22.
The KB of ammonia (NH3) can be calculated from the half-titration point by using the expression for the equilibrium constant of the reaction: KB = [NH4+][OH-]/[NH3]. At the half-titration point, half of the ammonia has been converted to ammonium (NH4+). By knowing the initial concentration of ammonia and the volume of titrant added to reach the half-titration point, you can calculate the concentration of NH4+ and OH- to determine KB.
The pKa of ethanol is approximately 16.
The pKa of Triethylamine is approximately 10.75.
The pKa of drotaverine is around 8.67.
The pKa value of pyridine is 5.2.