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One of the only ways is to make use of nucleophilic aromatic substitution (SN_Ar). Add a nitro group para to the OH, attack the OH carbon with 1 eq. ammonia, work it up with another eq., convert NH2 to a diazonium salt with NaNO2 + HCl @ 0~4 degrees C, then remove it with H3PO2.

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What is the mechanism involved in the bromination of phenol?

In the bromination of phenol, the mechanism involves the substitution of a hydrogen atom on the phenol ring with a bromine atom. This reaction is typically carried out in the presence of a brominating agent, such as bromine or a bromine-containing compound, under acidic conditions. The bromine atom replaces the hydrogen atom on the phenol ring, resulting in the formation of bromophenol.


Why is it that aniline has a high boiling point to phenol and phenol has a high boiling point than toluene and toluene has a high boiling point than benzene?

Aniline has a higher boiling point than phenol because aniline can form strong hydrogen bonds due to the presence of an amino group. Phenol has a higher boiling point than toluene because phenol molecules can form intermolecular hydrogen bonds because of the hydroxyl group. Toluene has a higher boiling point than benzene due to the presence of a bulky methyl group which increases Van der Waals forces between toluene molecules.


What is the equation for the reaction of aniline with acetic anhydride?

Positively charged carbon atom of the aldehyde's carbonyl group attacks p-position of aniline, having a negative charge. Compound 1 forms, with a positive carbon attacking a p-position of another aniline molecule.NH2-C6H5 + RC(O)H -> NH2-C6H4-CHR(OH) (compound 1)NH2-C6H4-CHR(OH) + NH2-C6H5 -> NH2-C6H4-CH(R)-C6H4-NH2 + H2OIn case of formaldehyde, the product is 4,4'-methylenedianiline (MDA).


What is the name of C6H5COOC2H5?

The formula is for benzyl acetate (as an example).


How does the reaction of phenol with Br2 proceed?

The reaction of phenol with Br2 proceeds through electrophilic aromatic substitution, where the bromine atom replaces a hydrogen atom on the benzene ring of phenol. This reaction is facilitated by the presence of the hydroxyl group on the phenol molecule, which activates the benzene ring towards electrophilic attack.

Related Questions

How to convert aniline to picric acid?

React aniline with HCl/NaNO2 (diazotisation) followed by reaction with KOH to give phenol. Nitration of phenol with fuming nitric acid gives picric acid (or trinitrophenol).


In lederer manasse reaction phenol is converted into?

This reaction is also called p-Hydroxy methylation of Phenol and phenol is converted into p-hydroxy benzyl alc.


Why is o-aniline phenol less soluble in water than m-aniline phenol?

In o-aniline phenol Intramolecular hydrogen bonding occurs which is not possible in meta and is responsible for less solubility


In Reimer Tiemann reaction of phenol with CCl4 to from the trichloromethane derivative what is the electrophile or the mechanism?

In the Reimer-Tiemann reaction, the electrophile is the carbene (CHCl3) that forms from the reaction of phenol with CCl4 in the presence of a base such as NaOH. This carbene then reacts with phenol to form the trichloromethane derivative. The mechanism involves the generation of the carbene intermediate, which attacks the phenol molecule to form the final product.


What would happen if you omitted phenol from the reaction?

If phenol is omitted from a reaction where it is a critical reactant, the expected products will not form, leading to an incomplete or entirely different reaction pathway. This could result in reduced yields or the formation of alternative products, depending on the role phenol plays in the chemistry involved. Additionally, the absence of phenol may affect the reaction’s kinetics and overall mechanism, potentially altering reaction conditions and outcomes.


What is the most reactive aniline or phenol?

Phenol is generally more reactive than aniline in electrophilic substitution reactions. This is because the hydroxyl group in phenol strongly activates the aromatic ring towards electrophiles, enhancing reactivity. In contrast, the amino group in aniline also activates the ring but can be deactivated by factors such as steric hindrance and the basicity of the nitrogen. Therefore, while both are reactive, phenol typically shows greater reactivity in these contexts.


What is the mechanism involved in the bromination of phenol?

In the bromination of phenol, the mechanism involves the substitution of a hydrogen atom on the phenol ring with a bromine atom. This reaction is typically carried out in the presence of a brominating agent, such as bromine or a bromine-containing compound, under acidic conditions. The bromine atom replaces the hydrogen atom on the phenol ring, resulting in the formation of bromophenol.


Why is it that aniline has a high boiling point to phenol and phenol has a high boiling point than toluene and toluene has a high boiling point than benzene?

Aniline has a higher boiling point than phenol because aniline can form strong hydrogen bonds due to the presence of an amino group. Phenol has a higher boiling point than toluene because phenol molecules can form intermolecular hydrogen bonds because of the hydroxyl group. Toluene has a higher boiling point than benzene due to the presence of a bulky methyl group which increases Van der Waals forces between toluene molecules.


What is the product of a reaction between bromine and aniline in non polar solvent?

The product of a reaction between bromine and aniline in a non-polar solvent is typically the bromination of aniline, where bromine substitutes a hydrogen atom on the benzene ring of aniline to form bromoaniline. This reaction is an electrophilic aromatic substitution reaction.


What is the equation for the reaction of aniline with acetic anhydride?

Positively charged carbon atom of the aldehyde's carbonyl group attacks p-position of aniline, having a negative charge. Compound 1 forms, with a positive carbon attacking a p-position of another aniline molecule.NH2-C6H5 + RC(O)H -> NH2-C6H4-CHR(OH) (compound 1)NH2-C6H4-CHR(OH) + NH2-C6H5 -> NH2-C6H4-CH(R)-C6H4-NH2 + H2OIn case of formaldehyde, the product is 4,4'-methylenedianiline (MDA).


What is the reaction of phenol with phosphorus pentachloride?

There is no reaction when their molar ratio is around 1...but when phenol is present in excess it gives triphenylphosphate....


What is the reaction product for bromine plus phenol?

The reaction product of bromine and phenol is 2,4,6-tribromophenol. In this reaction, the bromine replaces the hydrogen atoms on the phenol ring to form a tribrominated product.