A 22 cal is too small for good self defense.
Added:
Small calibre ammunition may not stop an attacker immediately. Ballistic science enforces small calibre, .22 or .32, ammunition may bounce around in a person if it penetrates them at all. I would suggest ammunition commonly used by law enforcement, 9mm, 40 cal, 45 cal, or 38 cal, of a hollow point variety. But since we are talking about firearms for defense there is nothing better than a shotgun. Just racking a round into the chamber could stop an aggressor.
What ever you choose, choose wisely and consult an expert before you make any final purchases.
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