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Yes, norepinephrine increases systemic vascular resistance (SVR). It acts primarily on alpha-adrenergic receptors, causing vasoconstriction of blood vessels, which leads to an increase in SVR. This effect is often utilized in clinical settings to manage hypotension and support blood pressure in critically ill patients.

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4mo ago

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Systemic vascular resistance (SVR) increases with hypothermia primarily due to vasoconstriction, which occurs as the body attempts to conserve heat and maintain core temperature. Cold temperatures activate sympathetic nervous system responses, leading to the release of norepinephrine, which constricts blood vessels. Additionally, hypothermia can impair endothelial function, reducing the production of vasodilators like nitric oxide, further contributing to increased SVR. This response helps redirect blood flow to vital organs, but can also lead to complications if prolonged.


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