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Lewis and Clark did not discover trade routes in the traditional sense, but their expedition from 1804 to 1806 mapped significant parts of the western United States, providing valuable information about the geography and resources of the region. They identified potential routes for trade and transportation, particularly the Missouri River and its tributaries, which could facilitate commerce with indigenous peoples and future settlers. Their journey also highlighted the feasibility of overland routes to the Pacific, influencing later westward expansion and trade.

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