Glutamate, the primary excitatory neurotransmitter in the brain, binds to specific receptors on the postsynaptic neuron, such as NMDA and AMPA receptors. This binding leads to the influx of sodium ions (Na+) and sometimes calcium ions (Ca2+), resulting in depolarization of the postsynaptic membrane. As a consequence, the postsynaptic neuron becomes more likely to generate an action potential, thus facilitating neural communication and contributing to processes like learning and memory. Additionally, excessive glutamate activity can lead to excitotoxicity, potentially damaging neurons.
the receptors on the postsynaptic membrane
Neurotransmitters are chemical messengers that transmit signals and information from the presynaptic neuron to the postsynaptic neuron at the synapse. They bind to receptors on the postsynaptic neuron, leading to changes in its membrane potential and triggering a new signal to be passed along the neural pathway. Some common neurotransmitters include acetylcholine, dopamine, serotonin, and glutamate.
GABA binds to GABA receptors on the postsynaptic neuron, leading to an influx of negatively charged chloride ions into the neuron. This hyperpolarizes the neuron, making it less likely to generate an action potential and thereby inhibiting its activity.
Excitatory postsynaptic potentials (EPSPs) are produced when neurotransmitters bind to excitatory receptors on the postsynaptic membrane, causing a depolarization of the neuron. This depolarization results in the opening of ion channels that allow positively charged ions, such as sodium and calcium, to enter the neuron, further depolarizing it. The cumulative effect of EPSPs from multiple synapses can reach the threshold for action potential initiation.
When neurotransmitters communicate an inhibitory message to the postsynaptic neuron:
a neuron from the axon terminal of which an electrical impulse is transmitted across a synaptic cleft to the cell body or one or more dendrites of a postsynaptic neuron by the release of a chemical neurotransmitter.
Spatial summation refers to the process by which multiple synaptic inputs from different locations on a neuron combine to produce a larger postsynaptic potential. This occurs when multiple presynaptic neurons release neurotransmitters simultaneously, leading to the cumulative effect of their excitatory or inhibitory signals. If the combined effect reaches the threshold, it can trigger an action potential in the postsynaptic neuron. Spatial summation is essential for integrating signals from various sources and determining the overall response of the neuron.
A postsynaptic potential occurs when neurotransmitters released from the presynaptic neuron bind to receptors on the postsynaptic neuron, causing a change in its membrane potential. This change can be either depolarizing (excitatory) or hyperpolarizing (inhibitory), influencing the likelihood of the postsynaptic neuron firing an action potential.
The tiny gap that the neurotransmitter has to diffuse across to reach the membrane of the postsynaptic neuron is called the synaptic cleft. It separates the axon terminal of the presynaptic neuron from the dendrite of the postsynaptic neuron.
The neurotransmitter that typically depolarizes postsynaptic neurons is glutamate. Glutamate binds to its receptors, such as AMPA and NMDA receptors, resulting in an influx of sodium ions (Na+) into the postsynaptic neuron. This depolarization can lead to the generation of an action potential if the depolarization reaches the threshold. Other neurotransmitters, like acetylcholine, can also cause depolarization in specific contexts.
Excitatory neurotransmitter
When two or more presynaptic neurons synapse with a single postsynaptic neuron in the central nervous system (CNS), it forms a convergent pathway. This allows for integration of multiple inputs onto a single neuron, influencing the postsynaptic neuron's response.