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yes Fragments resulting from the loss of stable neutral molecules like H2, H2O, CO, CO2, HCN, N2, HF, HCl, and HBr are common. Loss of a stable neutral molecule from the molecular ion results in an odd electron radical. For example, alcohols often loose H2O to form odd electron fragments:

R-OH+• -> [R-H]+• + H2O

Loss of a stable neutral molecule requires a rearrangment; more than one bond needs to be broken. - http://www.colby.edu/chemistry/PChem/StableLoss.html

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