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Radioactive decay is a chemical process that will occur indefinitely. It will eventually reach such a low level of radioactivity that any change is not measurable, but theoretically speaking this "reaction" never stops. Other than that I can't think of any reactions that will go on for that long without some change in their environment. Equilibrium reactions will shift regardless of how long ago they reached equilibrium if they detect some change (change in temperature, concentration of reactants or products, change in pressure or volume of their reaction vessel), but I don't think that's the sort of "goes on for years" you were asking for.

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16y ago

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