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Insertions or deletions causes much severe mutations because they generate frameshift mutations. For example: The sequence AUA-GGA-UAU-CCU is normally translated to I-G-Y-P A substitution such as AUC-GGA-UAU-CCU has no effect on the amino acid sequence because of redundancy in the codon table. (AUC and AUA both code for isoleucine) Another substitution such as AUA-GGA-CAU-CCU is a bit more severe because it changes the sequence to I-G-H-P. However, since only one amino acid is changed, the overall protein may only be slightly affected (however there are instances where a single amino acid change can drastically change the behaviour of the protein, e.g. sickle cell anemia). A deletion such as AU_-GGA-UAU-CCU is much more severe since to the ribosome, the new sequence is AUG-GAU-AUC-CU (a 'frameshift'), and it will be translated as M-D-I, which is completely different from the original sequence and will likely cause the vast majority of the amino acids after the deletion to be incorrect, creating a completely useless protein. An insertion such as AUA-GGA-UAAU-CCU will now be read as AUA-GGA-UAA-UCC-U, which is translated to I-G-Stop-S. This introduction of a premature Stop codon will truncate the protein, once again generating a useless protein.

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Related Questions

Is substitution mutations or insertion mutations worse?

Insertions generally are more harmful. An insertion causes a "frameshift" to occur, thus changing the entire amino acid sequence of the entire strand. Substitutions only change one base, which can sometimes not mess up the amino acid sequence at all.


Why are some mutation not harmful?

Some mutations can be deadly, harmful, or have no effect. Correct, not all mutations are harmful. Some mutations could even have a positive effect and help the creature adapt.


Are genetic mutations always harmful to the individual?

Genetic mutations are not always harmful to the individual. A few may be beneficial.


Is the following sentence true or false all mutations are harmful?

False. Not all mutations are harmful. Some mutations can be beneficial or have no effect on an organism. Mutations are simply changes in the genetic material of an organism, and their impact on an organism's traits can vary.


What are the various kinds of mutations?

Mutations differ and change according to many factors: 1- Site of occurrence: -Genetic mutations -Chromosomal mutations 2- The inheritance: -Somatic mutations -Gamete mutations 3- The origin: -Spontaneous (natural) mutations -Induced mutations 4- The harmful OR useful effects: -Undesirable mutations -Desirable mutations


Is point mutation lethal?

Point mutations can be lethal if they occur in a critical gene or region of the genome that is essential for survival. However, not all point mutations are lethal, as some may have no effect or may even provide a survival advantage. The impact of a point mutation on an organism depends on its location and the specific gene affected.


Are mutations always bad for an organism?

Mutations are changes in an organism's DNA that can be harmful, beneficial, or have no effect at all. While some mutations can be harmful and lead to diseases or disorders, others can be beneficial and provide an advantage in certain environments. So, mutations are not always bad for an organism.


What kind of mutations do you think would be harmful to an organism?

The majority of mutations that organisms get are harmful or neutral. Cancer is an example of a harmful mutation. So are certain genetic diseases and deformities, like an extra set of limbs.


Are all mutation harmful?

No, not all mutations are harmful. Some mutations may result in new traits that provide a survival advantage, while others may have no effect on an organism's fitness. Additionally, some mutations are neutral and do not impact an organism's health or survival.


Do all mutations affect the protein results?

No. Point mutations may have no effect on the protein, however, they can also be very harmful.


How do gene mutations happen?

mutation are caused by radiation and are 99.9% harmful


Can mutations be helpful orr are they always bad?

Mutations can be both helpful and harmful. Beneficial mutations can lead to adaptations that increase an organism's chances of survival or reproductive success, while harmful mutations can lead to genetic disorders or reduced fitness. The role of mutations in evolution is complex and depends on the specific environment and genetic context.