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Firstly, sodium methoxide is extremely toxic, so you want to handle it carefully without ever spilling (e.g. from an unsealed container). Secondly, methanol is hygroscopic and will pick up lots of water from the atmosphere. Water will hydrolyze sodium methoxide into methanol and sodium hydroxide. You wouldn't want your methanol to evaporate either.

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Q: Why should sodium methoxide 25 percent in methanol be kept tightly closed when not in use?
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