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The end of translation occurs when the ribosome reaches one or more STOP codons (UAA, UAG, UGA) on the mRNA.

At the ribosomal level, there is a competition between tRNAs and release factors. When a stop codon is reached, a release factor inserts into the A-pocket of the ribosome (keep in mind that a tRNA molecule cannot recognize a stop codon). Once the release factor is recognized by the ribosome, the polypeptide chain is signaled to release.

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