Yes; here are a few definitions of it to show you:
As you can see, 'unimportant matters', 'childish manner', which often has neg connatations, 'foolish', 'irrelavant' etc.
Remarkable
dainty
you understand the connotation of the word compared to the original word.
Important, meaningful are near synonyms of significant.
Context has the synonyms connotation, circumstance, condition, situation, ambience, frame of reference, background, relation, or connection.
a synonym for prattle is talk
Argue or debate can carry a negative connotation when used as a synonym for discuss.
Emaciated is a synonym of thin that carries the most negative connotation, suggesting extreme thinness often due to illness or malnutrition.
The word smelly has a negative connotation. A synonym with a positive connotation might be fragrant.
The synonyms for fastidious can include meticulous, exacting, or scrupulous. Words with a negative connotation are fussy or finicky.
If we're talking about an alternative synonym to the word picky that has no negative connotations, I would go with, 'Selective'.
Remarkable
Sometimes in this society it is used as a synonym for being thin, nd in that sense it can do, but when spoken of as the actual psychological illness, i wouldn't say it does.
dainty
Some choices: foolish, idiotic, fatuous, puerile
To revel is anotherverb commonly used interchangeably with gloat, but it does not have as much of a negative connotation. One could also use to exult.
you understand the connotation of the word compared to the original word.