Glucose transporters (GLUTs) are a family of proteins that facilitate the transport of glucose and other hexoses across cell membranes. They play a crucial role in regulating glucose homeostasis in the body, allowing cells to uptake glucose from the bloodstream for energy production. Different types of GLUTs are expressed in various tissues, each with specific functions and regulatory mechanisms. For instance, GLUT4 is insulin-responsive and predominantly found in adipose and muscle tissues, while GLUT1 is widely distributed and responsible for basal glucose uptake.
A family of proteins called GLUT carry glucose molecules across the cell membrane.
Reabsorption of filtered glucose from the lumen in the proximal convoluted tubule (PCT) is largely by means of the sodium-glucose cotransporter 2 (SGLT2). This transporter is responsible for actively transporting glucose and sodium from the renal tubule back into the bloodstream. The glucose is then further passively reabsorbed through the facilitative glucose transporter 1 (GLUT1) in the PCT cells.
The glucose transporter that is activated by insulin (glut 4) is a prime example.
The glucose transporter is a membrane bound protein that binds to glucose and mediates it's transport into or out of the cell.
Glucose transport into muscle cells is primarily facilitated by the glucose transporter 4 (GLUT4) carrier protein. This transporter is insulin-responsive and plays a crucial role in regulating glucose uptake by muscle cells to meet energy demands during exercise and recovery.
The sodium-glucose transporter (SGLT) is powered primarily by the sodium gradient across the cell membrane, which is maintained by the sodium-potassium pump (Na+/K+ ATPase). This transporter utilizes the energy from the co-transport of sodium ions (Na+) down their concentration gradient to drive the uptake of glucose against its concentration gradient. Essentially, as sodium ions enter the cell, they facilitate the simultaneous transport of glucose into the cell, enabling efficient glucose absorption in tissues such as the intestines and kidneys.
The glucose transporter that is activated by insulin (glut 4) is a prime example.
The glucose transporter that is activated by insulin (glut 4) is a prime example.
facilitated diffusion - a solute binds to a specific transporter on one side of the membrane and is released on the other side after the transporter undergoes a conformational change. includes glucose,urea,fructose,galactose,and some vitamins.
The glucose transporter that is activated by insulin (glut 4) is a prime example.
GLUT4 is the insulin-regulated glucose transporter found in adipose tissues and striated muscles (skeletal and cardiac) that is responsible for insulin-regulated glucose disposal."Allows equilibrium with blood-bidirectional".
Glucose molecules are moved into a cell via a transport protein called a glucose transporter. This process is facilitated diffusion, a type of passive transport that does not require energy. Glucose transporters help move glucose across the cell membrane down its concentration gradient.