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They can vary depending on what strains are expected to be in circulation during the flu season each year in each region. This is most often spoken in terms of hemispheres, Eastern, Western, Northern and Southern.

In the US they begin looking at what strains of influenza viruses are causing outbreaks in the Eastern Hemisphere in Asia just as the flu season is ending in the US in the spring of the Western Hemisphere. Through tracking by epidemiologists with the World Health Organization and various health departments of governments of individual countries (such as the CDC in the US), the types of flu in circulation during flu season on the other side of the world are analyzed.

They also monitor the flu season in the Southern Hemisphere, and by the time it is late summer in the US, the scientists have picked the three most prominent influenza viruses that are and have been spreading that year, are expected to be arriving in the season, and for which vaccines will be made for use in the US by seasonal flu shot time before the virus moves with the cooler weather into North America. The reverse happens as the Southern Hemisphere watches to see what is going to be in their next seasonal vaccine based on what they see causing outbreaks on the other side of the world as the season swings back to them.

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