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Sickle cell disease is caused by a single amino acid change in the hemoglobin beta chain, where the normal glutamic acid is replaced by valine due to a mutation in the HBB gene. This alteration leads to the production of hemoglobin S (HbS), which can polymerize under low oxygen conditions, causing red blood cells to distort into a sickle shape. These misshapen cells can obstruct blood flow, leading to pain and organ damage, characteristic of the disease. The altered hemoglobin's reduced solubility and increased tendency to aggregate are key factors in the pathophysiology of sickle cell disease.
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Why do sickle cells change shape and become "sickled" in individuals with sickle cell disease?
Sickle cells change shape and become "sickled" in individuals with sickle cell disease due to a genetic mutation that causes the hemoglobin in red blood cells to form long, rigid structures under certain conditions, leading to the characteristic sickle shape.
What common genetic variation which causes a change in the amino acid sequence in the structure of hemoglobin leads to what disease?
Sickle cell
What disease arises from an amino acid change in the protein hemoglobin?
Sickle Cell disease A disease that involves misshaped cells that can easily cause blood clots.
Did tiki barber have the sickle cell disease?
No, Tiki Barber does not have sickle cell disease. He is a retired NFL player who has been very active in various charitable causes, but sickle cell disease is not one of the health conditions he has publicly discussed.
What type of mutation causes sickle cell anemia?
Sickle-cell disease (SCD), or sickle-cell anaemia or drepanocytosis, is an autosomal co-dominant genetic blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape.
What are the causes of this disease and how is it transmitted sickle cell anemia?
it's caused by a mutation in the hemoglobin gene(a weird change that's basically in the red blood cell)disease is a group of genetic dis orders caused by sickle hemolobin(hgb s or hb s(
What are the causes of sickle-cell disease?
Sickle-cell Disease (SCD) is more common in those of African and Mediterranean decent; these people carry the sickle-cell trait; but not all who carry this gene develop the disease. This disease is caused by a genetic defect in an amino acid which shows in those who inherited this blood disease; SCD causes abnormal hemoglobin. This disease causes anemia which is caused by this mutation in the body's hemoglobin, B-globin chain. The abnormal gene causes irregular compounds in the red blood; hence the name Sickle-cell disease. The altered shape (crescent moon form) of the proteins inside of red blood cells causes them to clump and stick together leading to health issues.
What is the word for the genetic disorder that causes abnormal hemoglobin is known as?
sickle cell anemia. If you are only heterozygous for this disease it is simply called sickle trait.
Why is the sickle cell disease named that?
Because the condition causes the red blood cells to become sickle shaped rather than round.
What is sickle cell amenia?
Sickle Cell Anemia is an inherited blood disorder that causes the blood cells to change into a shape resembling a farmers sickle or a banana and makes blood flow difficult. There are many complications created by this disease. To learn more about the disease you could use this link: http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_Causes.html
Sickle cell disease is caused by a?
small change in the DNA of a single gene
How does disease affect the cell?
Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.
