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What is the type of mutation that causes hemophilia?
There is no single type of mutation that causes Hemophilia A. It is not the type of mutation but rather the location of the mutation within the genetic code.
What is the mutation in hemophilia?
Hemophilia is a mutation of either of the genes that make factor VII or IX. Hemophilia A is a mutation of the F8 gene and Hemophilia B is the mutation of the F9 gene. Both of these mutations occur on the sex-linked X chromosome.
Is hemophilia a insertion mutation?
Maybe
Is hemophilia a defect?
Hemophilia is a genetic mutation of the sex-linked X chromosome.
What is a carrier for hemophilia?
A carrier for hemophilia is a female who carries the genetic mutation for hemophilia on one of her X chromosomes, but does not exhibit symptoms of the condition herself. Carriers can pass on the gene mutation to their children, resulting in hemophilia in male offspring. Testing can confirm carrier status.
How is hemophilia inherited?
Hemophilia is carried on the X chromosome. If hemophilia is inherited by a son (1/3 of the cases are spontaneous mutations and not inherited) the gene was passed to him from the mother. If hemophilia is inherited by a daughter the gene could have come from either the mother, father or even both. (if from the father, he himself would have been a hemophiliac) A male only has one X chromosome so if the one he has has the gene for hemophilia he is a hemophiliac. The trait is considered recessive however incomplete dominance is know to occur frequently leading to the trait to at least partially be shown in females with a mutation on only one of their X chromosomes. When this occurs, women can demonstrate the symptoms and have low clotting factor levels similar to their male counterparts. A female with the genes for hemophilia on both X chromosomes will undoubtably have hemophilia as well.
Can two normal parents produce a hemophiliac son?
Approximately 1/3 of the cases of hemophilia are results of random mutations at the time of conception. Thus it is really not that uncommon for two people with completely standard genetics to have a child with hemophilia. Another possibility is that the mother was a carrier and didn't know. Since Hemophilia is due to a mutation on the X chromosome and females have two X chromosomes, it is possible for her to have no signs or reason to believe that she is a carrier. Even in cases with no family history prior, the spontaneous mutation can effect one of the mother's X chromosomes and then get passed on without her knowing she was a carrier.
How did queen Victoria become a carrier?
The reason she became a carrier for hemophilia is not known. There are several likely explanations, but no one knows the real reason. One of the most likely is that she got it from her father. Edward, Duke of Kent was in his 50's when Victoria was conceived so there is a chance that there was a mutation that happened. Another likely explanation is that it was just a mutation that happened when she was conceived and had nothing to do with either of her parents. There are other explanations such as her biological father was a hemophiliac or that it was her mother who carried the gene for hemophilia, but both are unlikely.
A woman is a carrier for hemophilia what are the chances for sons with hemophilia if the father does not have hemophilia?
Since the gene for Hemophilia is carried on the X chromosome and males pass only their Y chromosome onto their sons, no their sons should not have hemophilia. Of course all daughters of a male with hemophilia will be carriers of the mutation since they with receive his X chromosome, not the Y.
Is hemophilia caused by inbreeding?
No, hemophilia is a genetic disorder caused by a mutation in the genes responsible for blood clotting, and it is not directly caused by inbreeding. Inbreeding can increase the likelihood of inheriting genetic disorders, including hemophilia, if the mutation is present in the family's gene pool.
Can women be hemopheliacs?
Yes, women can have hemophilia. Depending on the definition of hemophilia you follow, there are two main ways in wich females can have hemophilia.The first way we'll look at is accepted by everyone and there i no reason for debate whatsoever. This is when a female has a mutation for hemophilia on both of her X chromosomes. This is extremely rare. For a female to have mutations on both X chromosomes, she would have to have either;A. inherited the mutation from both parents (meaning that her father was a hemophiliac and her mother carried the gene) or;B. inherited the mutation from one parent at the same time she had a spontaneous mutation occur on the other X chromosome, or;C. Had spontaneous mutations to both X chromosomes at the same time.The next way a female can have hemophilia is a subject of some debate (wich at least to me seams silly as there should be no debate at all). Females with a mutation on a single X chromosome often demonstrate bleeding problems and Clotting Factor Protein levels like those seen in non-controversial cases of hemophilia. In recent years doctors have begun recognizing that these females with low clotting factor levels (historically called symptomatic carriers) need to be treated in the same way as any other hemophiliac with equivalent factor levels. This new approach puts more weight on the phenotypic results rather than the genotypic.
Does frame shift mutation affect hemophilia?
Frame shift mutations that occur on the X chromosome and within the potion of code that controls the formation of clotting factors can cause hemophilia. Frame shift mutations are only one of many types of mutations that can cause the disorder. For hemophilia it's not so much the type of mutation but the location of the mutation within the genetic code.
