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Yes! NSAIDS, like ibuprofen cause vasoconstriction, they make the arteries in your kidneys smaller so no blood can get to it... this can cause acute renal failure if you take ibuprofen regularly or at high doses. It's a cumulative effect... so just by taking ibuprofen regularly for a while can damage your kidneys. It can also cause fluid retention, aplastic anemia, GI distress (upset), and ulcers!

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