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One of them was quinine. It is contained in tonic water, which made gin and tonic so refreshing to those in colonial Africa. Before the isolation of quinine, powdered Peruvian Bark, isolated from Cinchona trees, was used to treat patients with malaria. Quinine was isolated from the bark in 1817, and a synthetic form is now used. In the mid 1700s, willow bark was noted to have an effect against malaria. While willow bark did not cure the disease, it reduced the fever, pain, and fatigue of patients with malaria. The active compound in the bark was salicin, a compound that is related to aspirin.

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16y ago

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