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The HSV-8 virus causes Herpes Simplex 8.

HSV-8 is associated with Kaposi's sarcoma, a cancer which can manifest in people who are immunocompromised (weakened immune system due to heavy steroid use, HIV/AIDs, or other conditions). Kaposi's sarcoma usually stays under control of the immune system unless something else is weakening the immune system. HSV-8 can manifest the same as HSV-2 as to be nearly indistinguishable. It is thought that HSV-8 is more prevalent in areas such as Southeast Asia and India and centered in populations of those who are involved in prostitution or use of the services of prostitutes, among men who have sex with other men, and certain other populations.

HSV-8 is a gammaherpesvirunae. It targets endothelial cells of the skin. Less is known about HSV-8 than the more common strains. It is thought to be transmitted through the exchange of body fluids, such as in unprotected sexual intercourse, particularly where skin is rubbed raw or blood can be transmitted (this is especially true with unprotected anal intercourse).

Kaposi's sarcoma- associated herpes virus (KSHV)GammaherpesvirinaeEndothelial cellsUnknownExchange of body fluids?

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