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The Clonal Selection Theory explain how the immune system can be both diverse and very specific at the same time.The theory states:
- All antibodies are precommitted to making a single antibody with a single specificity
- A single cell produces only one antibody which interacts with only one antigen with the highest specificity
- When the right antigen interacts with that cell, it leads to clonal expansion and proliferation of that cell, so that many daughter-cells are made with the exact same specificity
- The ability to recognise an antigen is dependent on a receptor, and the receptor is a product of the same cell that secretes the antibody. This ensures that made antibodies will fit with the antigen they are supposed to bind.
A clone is defined as a group of cells in which all daughter cells are equal in their specificity
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What is clonal selection theory?
Clonal selection theory explains how the adaptive immune system selects and amplifies immune cells (such as B cells and T cells) that are specific to antigens. When a pathogen enters the body, immune cells with receptors that match the antigen are selected for activation and proliferation, leading to a targeted immune response. This theory is fundamental to understanding how the immune system responds to infections and develops immunological memory.
According to the clonal selection theory foreign antigens select and interact with surface receptors only on the membranes of those specific lymphocytes that are genetically capable of making antibod?
False
What is clonal selection responsible for?
Clonal selection is responsible for the production of a large population of identical B or T cells that specifically recognize and target a particular antigen. This process is critical for the adaptive immune system's ability to mount a targeted immune response against pathogens.
What is the basis of immunological memory?
Clonal selection and differentiation of lymphocytes provide the basis for immunological memory.
What area is antigen challenge and clonal selection most likely to occur?
Antigen challenge and clonal selection are most likely to occur in the secondary lymphoid organs, such as the lymph nodes and spleen. These organs are where antigens encounter immune cells, triggering an immune response and the selection of specific immune cell clones.
What nonlymphocyte cell is a central actor in clonal selection?
Antigen-presenting cells (APCs) are nonlymphocyte cells that play a central role in clonal selection. They present antigens to T cells, triggering the immune response and selection of specific clones of T cells that can recognize and respond to the antigen.
What is the clonal selection theory as it applies to B cells?
1. An antigen presenting cell presents antigen on Class II MHC to a Helper T cell activating it 2. At the same time a B cell that has taken up and degraded the same pathogen displays antigen on its class II 3. The activated helper T cell binds to the B cell releasing cytokines and activating it 4. The activated B cell proliferates and differentiates into: 1) memory B cells 2) antibody-secreting plasma cells that produce antibodies specific for the pathogen
What type of selection pushed Darwin's theory?
Natural Selection
What theory does the natural selection belong to?
Darwin's theory of evolution.
What is drwin's theory?
Natural selection
What theory proposes that nature changes species?
theory of natural selection
What is the theory proposed by Darwin?
The theory of evolution by means of natural selection.
