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A definitive diagnosis of primary liver cancer is typically made through a combination of medical history, physical examination, and various diagnostic tests. The key steps involved in diagnosing primary liver cancer (hepatocellular carcinoma or HCC) include:

Medical History and Physical Examination: The doctor will take a detailed medical history, including information about risk factors such as hepatitis B or C infection, cirrhosis, and alcohol consumption.

A physical examination may be performed to assess the patient's overall health and look for signs of liver disease, such as jaundice or abdominal swelling.

Blood Tests: Blood tests may be conducted to assess liver function and to check for markers associated with liver diseases and cancers. These markers may include alpha-fetoprotein (AFP) and liver function enzymes.

Imaging Studies: Imaging tests are crucial for visualizing the liver and identifying any abnormal growths. Common imaging techniques include ultrasound, CT (computed tomography) scans, and MRI (magnetic resonance imaging).

These tests help determine the size, location, and characteristics of the liver lesions.

**Biopsy:**In some cases, a liver biopsy may be performed to obtain a sample of tissue from the liver for examination under a microscope. This is often considered the most definitive method for diagnosing liver cancer.

The biopsy can help confirm the type of liver cancer, assess its grade and stage, and guide treatment decisions.

Additional Tests: Additional tests may be conducted to assess the extent of the disease and whether it has spread to other parts of the body. These may include bone scans, chest X-rays, and other imaging studies.

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