Osteodystrophy
The catch-all phrase is osteodystrophy, literally "bone mis formed".
G. V. Ashcroft has written: 'Renal rickets' -- subject(s): Renal osteodystrophy
The mutations are in the Gs-alpha subunit ( for example, Arg485 to His) and leads to pseudohypoparathyroidism, also known as Albright Hereditary Osteodystrophy.
A HOD dog is a dog that has Hypertrophic Osteodystrophy. HOD is a bone disease that occurs in fast-growing large and giant breed dogs.
this is the complex term.pathology depends on the factor .for eg...congenital malformation of bone is called as dysostoses.
Alfacalcidol is a type of vitamin D used to treat a number of conditions such as osteomalacia (rickets), familial hypophosphatemia, hypoparathyroidism, osteodystrophy, vitamin D deficiency, and so on. Also, this medication is used to increase the levels of vitamin D, calcium, and phosphate in the body. It belongs to a group of medicines called vitamin D analogues.
Osteodystrophy - Defective bone formations, often due to hyperphosphorosis (too much phosphorous in the diet) is caused by feeding a diet consisting entirely of, or rich in, muscle meat: this lacks calcium and leads to a deficiency of this vital mineral. The problem usually manifests itself in young ferrets (six to twelve weeks) who have difficulty walking, moving instead with the gait of a seal, with the legs sticking out to the side of the body rather than pointing to the floor: death is common
Pseudohypoparathyroidism is a condition caused by resistance to the parathyroid hormone. Patients have a low serum calcium and high phosphate, but the parathyroid hormone level is appropriately high.Type 1a pseudohypoparathyroidism has a characteristic phenotypic appearance (Albright's hereditary osteodystrophy), including short fourth and fifth metacarpals and a rounded facies.Type 1b pseudohypoparathyroidism lacks the physical appearance of type 1a, but is biochemically similar.The term pseudopseudohypoparathyroidism is used to describe a condition where the individual has the phenotypic appearance of pseudohypoparathyroidism type 1a, but is biochemically normal.hypocalcemiahyperphosphatemiaelevated parathyroid hormone (hyperparathyroidism) [1]1. http://en.wikipedia.org/wiki/Pseudohypoparathyroidism
Pseudo means -like or similar. The best way to understand this is to break it down. Hypoparathyroid is an underactive parathyroid gland, so too little parathyroid hormone is released into the blood - this causes low calcium levels in the blood. Pseudo-hypoparathyroid is like hypoparathyroid but instead of lack of parathyroid hormone causing the low calcium levels, it is resistance to the hormone at the receptor levels - hence it is pseudo- because it is like hypoparathyroid but the parathyroid hormone level is actually normal. It is associated with other abnormalities like short stature and short metacarpals (hand bones). Pseudo-pseudo-hypoparathyroid has nothing to do with calcium, but it is "-like" pseudohypoparathyroid in terms of bone abnormalities. Hope that helps.
Around the age of three or four weeks, they should be introduced to small amounts of puppy food. At first, they may play in it but will learn soon enough what to do with it. By the time they're weaned (about seven to eight weeks), they should be able to get complete nutrition from solid food. Puppies of small breeds (under 20 pounds as an adult) will reach full maturity by nine to 12 months, while large breeds (over 50 pounds) may not reach full maturity until the age of two. Unless you have other pets, your small-breed puppy is generally best fed with the free-feeding method. Most of them will develop good eating habits with food available to them at all times. Larger breed puppies should be fed with the portion control method. Some of the larger breeds are prone to bone growth problems and if they are overfed, excess protein and calcium can put them at higher risk for hypertrophic osteodystrophy (HOD), osteochondritis dissecans (OCD), and hip dysplasia.
DefinitionPseudohypoparathyroidism is a genetic disorder that is similar to hypoparathyroidism, but which results from the body's lack of response to parathyroid hormone rather than decreased production of the substance.Alternative NamesAlbright's hereditary osteodystrophy; Types 1A and 1B pseudohypoparathyroidismCauses, incidence, and risk factorsThe parathyroid glands help control calcium use and removal by the body. They do this by producing parathyroid hormone, or PTH. PTH helps control calcium, phosphorus, and vitamin D levels within the blood and bone.Persons with pseudohypoparathyroidism produce the right amount of PTH, but the body is "resistant" to its effect. This causes low blood calcium levels and high blood phosphate levels.Pseudohypoparathyroidism is caused by abnormal genes. All forms of pseudohypoparathyroidism are very rare.Type Ia is inherited in an autosomal dominant manner. That means only one parent needs to pass you the defective gene in order for you to develop the condition. The condition causes short stature, round face, and short hand bones, and is also called Albright's hereditary osteodystrophy.Type Ib involves resistance to PTH only in the kidneys. Type Ib is less understood than type Ia. Type II is very similar to type I in its clinical features, but the events that take place in the kidneys are different.Type 2 pseudohypoparathyroidism also involves low blood calcium and high blood phosphate levels, but persons with this form do not develop the physical characteristics seen in those with Type 1a.All forms of pseudohypoparathyroidism are very rare.SymptomsSymptoms are related to low levels of calcium and include:CataractsDental problemsNumbnessSeizuresTetany (a collection of symptoms including muscle twitches and hand and foot spasms)Persons with Albright's hereditary osteodystrophy may have the following symptoms:Calcium deposits under the skinDimples that can replace knuckles on affected fingersRound face and short neckShort hand bones, especially the bone below the 4th fingerShort statureSigns and testsBlood tests will be done to check calcium, phosphorus, and PTH levels. Urine tests may also be done.Other tests may involve:Genetic testingHead MRI or CT scan of the brainTreatmentCalcium and vitamin D supplements are prescribed to maintain proper calcium levels. If blood phosphate levels remain high, a low-phosphorus diet or medicines called phosphate binders (such as calcium carbonate or calcium acetate) may be necessary.Expectations (prognosis)Low blood calcium in pseudohypoparathyroidism is usually milder than in other forms of hypoparathyroidism.ComplicationsPatients with type Ia pseudohypoparathyroidism have an increased rate of other endocrine abnormalities (such as hypothyroidism and hypogonadism).Complications of hypocalcemia associated with pseudohypoparathyroidism may include seizures and other endocrine problems, leading to lowered sexual drive and lowered sexual development, lowered energy levels, and increased weight.Calling your health care providerCall your health care provider if you or your child have any symptoms of hypocalcemia or other features of pseudohypoparathyroidism.ReferencesWysolmerski JJ. Insogna KL. The Parathyroid Glands, Hypercalcemia, and Hypocalcemia. In: Kronenberg HM, Schlomo M, Polansky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. St. Louis, Mo: WB Saunders; 2008: chap. 266.Bringhurst FR, Demay MB, Kronenberg HM. Disorders of Mineral Metabolism. In: Kronenberg HM, Schlomo M, Polansky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. St. Louis, Mo: WB Saunders; 2008: chap. 27.