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During Parasympathetic action when acetlcholine is released in the sphincter muscles then the M3 muscarinic receptors stimulate Gq protein and this in turn activate Phospholipase C (PLC). PLC then cleaves the phospholipid. In the process, phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved into diacyl glycerol (DAG) and inositol 1,4,5-triphosphate (IP3). DAG remains bound to the membrane and IP3 is released as a soluble structure in the cytosol. IP3 then diffuses through the cytosol to bind to IP3 receptors, particularly the calcium channels in the endoplasmic reticulum (ER). These channels are specific to calcium and allow only the passage of calcium to move through. This causes the cytosolic concentration of calcium to increase and cause the cascade of contractile machinery and the spinchter will contract and tighten up.
What else can I help you with?
How would a drug that blocks acetylcholine release affect muscle contraction?
All I know is that acetylcholine is the only neurotransmitter that transmits signals from nerves to skeletal muscles, so anything that blocks it would probably have the effect of you wanting to move your muscles, but either not being able to, or moving weakly. Just a (educated) guess. It would cause spastic paralysis (muscles are contracted and unable to relax)
A poisonous gas destroys the enzyme that breaks down acetylcholine. What effect do you think this gas has on the body?
If the enzyme that breaks down acetylcholine is destroyed, acetylcholine levels in the body will increase. This can lead to overstimulation of muscles and nerves, causing symptoms like muscle twitching, paralysis, respiratory failure, and even death.
What precautions need to be taken when using external sphincter electromyography?
Patients who are taking muscle relaxants or drugs that act like or have an effect on the neurotransmitter acetylcholine (cholinergic or anti-cholinergic drugs) should tell the doctor since they will change the test results. The results will.
How does a depressant affect the brain function?
They affect GABA, NMDA, opiod, adrenergic, histamine and acetylcholine receptors in your brain. Depressants can effect other parts of your brain aswell, these are just the parts of it that actually cause the depressant effects of the drugs. Alcohol for example effects the GABA, NMDA, acetylcholine and serotonin receptors but it's effect on the serotonin receptor doesn't cause any depressant effect but rather adds to the euphoric effects of alcohol.
What is a cholinomimetic agent?
A drug or compound that acts like acetylcholine (ACh). Acetylcholine is a neurotransmitter. In the peripheral nervous system (PNS), acetylcholine activates muscles. In the central nervous system (CNS), acetylcholine tends to cause decreased muscle contractions. These two responses are opposite. ACh Receptor agonists (booster of the effect) are used to treat myasthenia gravis and Alzheimer's disease. ACh receptor antagonists block muscle contractions causing paralysis. The bite of the Black Widow spider does this.
What do you think the effect of breaking down acetylcholine is on muscle contraction?
Breaking down acetylcholine can lead to muscle relaxation because acetylcholine is a neurotransmitter that stimulates muscle contraction. When acetylcholine is broken down, the signal for muscle contraction is reduced, resulting in muscle relaxation.
What is Overall effect of curare in an organism?
Curare is a plant-derived poison that blocks nicotinic acetylcholine receptors at the neuromuscular junction, leading to muscle relaxation and paralysis. This can result in impaired breathing and death if respiratory muscles are affected.
What is the effect of pilocarpine on heart rate?
Pilocarpine stimulates the release of acetylcholine from parasympathetic neurons. Therefore, it stimulates the effect of vagal stimulation on the heart.
What effect will organopesticides have on muscle tissue?
Organopesticides will increase the severity of muscle contraction beyond normal conditions. Acetylcholine esterase inhibition will allow a more than normal amount of acetylcholine to bind to receptors.
What will be the effect of cholinergic agonist on the pyloric sphincter?
A cholinergic agonist will cause the pyloric sphincter to relax, leading to increased gastric emptying. This is because cholinergic stimulation promotes smooth muscle relaxation in the gastrointestinal tract, allowing food to pass through the pyloric sphincter more easily.
Does cardio exercise have a positive affect on abs?
Cardio exercise has a wonderful effect on your health. However, it won't really affect your abs. You'll need to do exercises specifically to tone the abdominal muscles to have a positive affect on that region.
What is the effect the muscle?
what effect the muscles are the cold water
