There are so many horrible diseases in the world, and it's difficult to name the most horrible one, as it differs from a place to another place, for example Heart diseases and cancer may be the most horrible diseases in developed countries, but not in developing or under-developed countries, where infectious disease still comes first.
Disease
They mainly brought disease such as smallpox or measles, but they also brought muskets.
the most harmful disease in the world is cancer (it kills the most people).
Aids
Black death
Hurricane katrina and hurricane Ivan
The most devastating world war 1 weapons had to be machine guns, mustard gas, and artillery. Mustard gas was a really nasty chemical that created big blisters on the flesh and lungs if inhaled.
It was the largest and most devastating war in human history.
Tooth decay The most common noncontagious disease is periodontal disease, such as gingivitis or inflammation of the gums. Gum disease is the most common disease in the world, and poor oral health is generally recognised as an indicator of social deprivation.
Well, this time, a magical sky dude flooded the Earth...
The second world war has been terribly devastating. The devastating hurricane caused serious damages in that city.
Coronary artery disease.