It effect almost everyone in england.
people
It killed everyone...
Black Death Plague killed half of world's population. So it affected very negatively.
transdermal
Yes. Death, which is permanent.
It killed a lot of people.
Europe Africa Asia
Religious people thought that the plague was sent by God as a punishment for sin. Because of all the widespread death due to the whole plague Religious people found it diffeicult to gain trust in their religion because of the death. It did effect Europe in a reasonably large way. However one thing that was not hindered by the plague was the Pope who locked him self in locked quaters. He did not catch either plague.
because the plague was so deadly
no
Buccal administration is considered both local and systemic. When a medication is absorbed through the buccal mucosa in the mouth, it can enter the bloodstream directly (systemic effect) or act locally within the oral cavity.