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What causes sickle cell allele?
The sickle cell allele is caused by a mutation in the HBB gene, which encodes a protein called hemoglobin. This mutation causes an abnormal form of hemoglobin (HbS) to be produced, leading to the characteristic sickle shape of red blood cells in individuals with sickle cell disease.
What type of mutation causes sickle cell anemia substitution deletion insertion mutagen?
The type of mutation that causes a defect in the gene (causing sickle cell anaemia) is a substitution mutation.A single nucleotide substitution (A to T) in the β-globin gene causes the amino acid valine to replace glutamic acid. This changes the resulting protein, causing a haemoglobin with an abnormal shape to be created.
Why does sickle cell hemoglobin migrate slower than normal hemoglobin during electrophoresis?
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
What protein does does sickle-cell anemia affect?
Sickle cell disease is an inherited blood disorder that affects red blood cells.
What is glutamate replaced by in sickle cell anemia?
In sickle cell anemia, glutamic acid is replaced by valine due to a single base change in the gene that codes for hemoglobin. This substitution causes the hemoglobin protein to form abnormal sickle-shaped red blood cells, leading to the symptoms of the disease.
What protein is not normal in people with sickle- cell disease?
Hemoglobin
What protein is not normal in people with sickle-cell disease?
It is Hemoglobin
Why does sickle cell hemoglobin migrate slower than normal hemoglobin during gel electrophoresis?
because of the change of AA- in normal cell- from Glutamic acid (negativity charged) to Valine (uncharged) -in sickle cell- the charge will be missing in the sickle cell that why the electrophoresis will become slower because of the missing charge
What is the causative agent of sickle cell?
Sickle cell disease is caused by a mutation in the gene that encodes for hemoglobin, a protein in red blood cells that carries oxygen. This mutation results in the production of abnormal hemoglobin known as hemoglobin S, which causes red blood cells to become sickle-shaped and less flexible.
Can sickle cell anemia cause pneumonia?
no it dose not sickle cell anemia causes death only if African Americans
When a mutation in the hemoglobin gene causes what disorder?
While technically there are more than one, the main one by far is sickle cell anemia.
How many amino acids need to be incorrect to prevent protein from working properly in sickle cell anemia?
Just one incorrect amino acid prevents protein from functioning properly in sickle cell anemia.
