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glucose travel from small intestine to arms by hepatic portal vein

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What is the route a glucose molecule takes from the small intestine to a leg muscle cell?

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Why is rectal the most effective route of administration for adderall?

the terminal end of the colon is not acidic. in fact, as you go from the stomach-small intestine-colon, the pH gradually increases from 2 to around 8. Amphetamines salts (like the ones in adderall) are weakly basic and have a pka of around 6.6. because of this, most of the drug will be in an unionized form (will not have a charge on the amine in the structure) which makes it very hydrophobic (fat loving/favorable). Because of this, the amphetamines do not have a problem passing through the cells lining the colon. This, along with the enormous amounts of capillaries underlying the colon endothelial cells will allow for a fast, and very good permeability into the systemic circulation. Also to note-this route by passes 1st pass metabolism( the process of the drug going from the intestine to liver for excretion/modification of drug), thus you get mostly all of the amphetamines into your system without any of it being hindered/excreted by the liver.


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