Acetylcholine and norepinephrine both affect smooth muscle contraction. They stimulate contraction in some muscles and inhibits contraction in others.
Smooth Muscle Cells
acetylcholine (ACh)
Sarcolema receptors
Occurs when acetylcholine (ACh) accumulates in the neuromuscular junction. It is called a tetanic contraction.
"A muscle cell remains contracted until the release of acetylcholine stops and an enzyme produced at the axon terminal destroys any remaining acetylcholine."
the degree of muscle stretch is affect the strength or force of skeletal muscle contraction
Acetylcholine release is necessary for skeletal muscle contraction, because it serves as the first step in the process, enabling the subsequent cross-bridge formation. A muscle's ability to contract depends on the formation of cross-bridges between myosin & actin filaments. A drug that blocks acetylcholine release would interfere with this cross-bridge formation and prevent muscle contraction
A neurotransmitter that causes muscle movement is called Acetylcholine. Acetycholine acts as on both the central nervous system and the peripheral nervous system.
Acetylcholine is the excitatory neurotransmitter released by neurons innervating skeletal muscles. Acetylcholine release stimulates muscle contraction by acting at the nicotinic-acetylcholine receptor on the surface of the muscle cell.
Acetylcholine is released into the neuromuscular junction by the axon terminal
binding of acetylcholine to membrane receptors on the sarcolemma
A signal is generated in the motor cortex of the brain, and travels down the spinal cord to the affected motor neurons. As the action potential travels down the axon of the final motor neuron, it causes calcium influx and exocytosis of acetylcholine-containing vesicles, releasing acetylcholine into the neuromuscular junction. From there, acetylcholine binds with receptors on the muscle fiber end plates, where it depolarizes the muscle fiber, causing contraction of the muscle.