Tetany
Citrate in blood binds to calcium ions, forming complexes that are not available for biological functions. This decreases the amount of free calcium in the blood, leading to hypocalcemia. Additionally, citrate can chelate calcium in the blood, further reducing the level of ionized calcium available for use in blood clotting and nerve function.
myasthenia gravis
Calcium supplements are useful primarily to treat hypocalcemia. This is a nutritional issue that typically arises around pregnancy. In dogs, pregnancy hypocalcemia tends to be pre-parturient (before birth) and causes a tonic paralysis (rigid paralysis). In dairy cattle, hypocalcemia tends to be post-paturient (after birth) and causes a flaccid paralysis (floppy or loose paralysis). In both cases, careful administration of intravenous calcium can reverse the paralysis in a matter of hours.
A neuromuscular blocker causes temporary paralysis by blocking the transmission of nerve stimuli to the muscles. This type of drug is used adjunctively to anesthesia to produce paralysis.
There are several different conditions that can cause calcium deposits in the eye. These include hypocalcemia, gout, renal failure, and chronic inflammation.
Scoliosis is a side-to-side curvature of the spine. Neuromuscular scoliosis is due to loss of control of the nerves or muscles which support the spine. The most common causes of this type of scoliosis are cerebral palsy and muscular dystrophy.
a cats weakness is ventroflexion of the neck is a common presentation in cats with neuromuscular causes of acute weakness.
There are several causes of a limp. Often it is caused by pain, weakness, neuromuscular imbalance or a skeletal deformity. However, the most common cause of a limp is physical trauma.
The causes of hypotonia are varied and numerous. Some involve trauma to, or diseases of, the brain or spinal cord (CNS), while others affect the peripheral nerves, neuromuscular junction, or the muscles themselves.
Yes, hypercalcemia causes nervous system depression - the opposite of (see below) According to the Human Anatomy and Physiology Textbook by Marieb, hypocalcemia causes neuron excitation and if severe enough, leads to tetany and then paralysis. this is because both serum calcium and intracellular calcium are increased. The reason hypocalcemia causes neuron excitation (contrary to the above logic) is because a decrease in extracellular calcium concentration increases the neuron membrane's permeability to sodium and allows sodium to easily depolarize the neuron's membrane and cause an action potential. Additionally The membrane threshold becomes refractory to depolarization thus many of the symptoms are related to the loss of cell membrane excitability. How extracellular calcium controls sodium membrane permeability is another question.
Metubine works by blocking the transmission of nerve impulses at the neuromuscular junction, specifically at the nicotinic acetylcholine receptors. This prevents the muscle from receiving signals to contract, leading to muscle paralysis.