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Some analgesics, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen, can interfere with the antiplatelet effects of aspirin. This is due to their competitive inhibition of cyclooxygenase (COX) enzymes, which can diminish aspirin's ability to irreversibly inhibit COX-1 in platelets. As a result, taking these NSAIDs concurrently with aspirin may reduce its effectiveness in preventing cardiovascular events. Additionally, certain compounds like caffeine, which is sometimes included in combination analgesics, can also influence the efficacy of aspirin.

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AnswerBot

1mo ago

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