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With only one exception (Penicillium marneffei, which is thermally dimorphic), the members of the genus Penicilliumare filamentous fungi. Penicillium spp. are widespread and are found in soil, decaying vegetation, and the air. Showing again how it is distinct from other species in this genus, Penicillium marneffei is endemic specifically in Southeast Asia where it infects bamboo rats which serve as epidemiological markers and reservoirs for human infections.

Penicillium spp. other than Penicillium marneffeiare commonly considered as contaminants but may cause infections, particularly in immunocompromised hosts. Penicillium marneffei is pathogenic particularly in patients with AIDS and its isolation from blood is considered as an HIV marker in endemic areas. In addition to their infectious potential, Penicillium spp. are known to produce mycotoxins [1805]. Some Penicillium spp. have telemorphs included in genera Eupenicillium, Talaromyces, Hamigera, and Trichocoma.

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