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Hernan Cortez conquered the Aztec Empire in 1521, with the help of more than 200,000 Tlaxcalan allies -- who were bitter enemies of the Aztecs -- and a smallpox epidemic that decimated the Aztec population between 1519 and 1521. After the Fall of Tenochtitlan, central Mexico became part of the Spanish Empire, and Hernan Cortez became its first viceroy.

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