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Columbus's voyages in 1492 initiated widespread contact between Europe, the Americas, and Africa, leading to profound consequences for all involved. For Native Americans, this resulted in devastating population declines due to disease, violence, and displacement, fundamentally altering their societies. Africans were increasingly caught in the transatlantic slave trade as European powers sought labor for their colonies. Meanwhile, Europeans gained access to new resources and lands, leading to economic expansion and the eventual establishment of colonial empires.

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