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The Black Death pandemic of 1349 is considered to be one of the major events in world history, and it is still the subject of medical, historical, and sociological analysis. The evidence of the plague is found in the broad swath it cut across North Africa, Asia, and Europe, its terrifying symptoms, and its impact.
Ancient history includes vivid descriptions of epidemics that seized their victims suddenly and produced an agonizing death. One such episode occurred in Athens, Greece, in 430 B.C.E., and another occurred in Egypt, Persia, and Rome a century later. Some historians believe these lethal outbreaks were caused by the same disease responsible for the Black Death the Bubonic Plague. Other historians, though, note some differences between the symptoms observed in the ancient episodes and those reported during the fourteenth century.
This plague was most probably originated from Mongolia and "carried by fleas on black rats." It quickly spread all the way to the Black Sea across parts of modern day Russia, where Italian traders caught it and returned home with it. As a result of an already "undernourished population," the Bubonic Plague had devastating effects throughout Europe. It could be attested that the Bubonic Plague has serious consequences in the social, economic, and psychological aspects of the Late Middle Ages throughout Europe. Furthermore, their effects also had considerable social and cultural consequences during the following Renaissance period.
Historians consider the burning from the London City in 1666 a last resort to combat the Bubonic Plague.

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