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How is hemoglobin constructed?

Normal adult hemoglobin has a pair each of alpha-globin and beta-globin molecules


What is Hb Bart's?

Hb Barts is associated with one of the alpha-Thalassemias, namely homozygous alpha^0. The absence of all four alpha globin genes results in the alpha globin chain not being produced. The only types of haemoglobin that can be produced are Gower 1 (zeta2eta2) and Portland (zeta2gamma2) which are both embryonic haemoglobins. At around 6wks the alpha globin production is ~50% of the total. In the absence of globin chains the fetal haemoglobin (alpha2gamma2) cannot be produced so the gamma globulin chain precipitate out in the red blood cells as tetramers (gamma4). These tetramers are referred to as Hb Bart.


What are the differences between the alpha chain and beta chain in terms of structure and function within a protein complex?

The alpha chain and beta chain in a protein complex differ in their structure and function. The alpha chain typically forms the core of the protein complex, providing stability and structural support. In contrast, the beta chain often plays a role in binding other molecules or ions, contributing to the overall function of the complex. These differences in structure and function allow the alpha and beta chains to work together to perform specific tasks within the protein complex.


How many polypeptide chains form the globin portion of the molecule?

4 polypeptide chains, each bound to a heme group to form hemoglobing


What is an alpha chain?

An alpha chain is a component of certain types of proteins, such as antibodies and hemoglobin. It is a polypeptide chain that forms part of the structure of these proteins and plays a crucial role in their function. The alpha chain is usually one of the two different types of chains (the other being a beta chain) that come together to form a functional protein complex.


Can a chain structure model be a alpha or beta?

alpha


How many globin molecules are in each hemoglobin?

There are four nearly-identical individual protein chains in hemoglobin.


What is importance of hemoglobin H?

Hemoglobin H disease is a type of Thalassemia. Thalassemia is a genetic (inherited) disorder, affecting the haemoglobin's structure, more precisely, the protein chains of the haemoglobin, which are responsible for carrying the oxygen and carbon dioxide inside the Red Blood Cells. If any of these protein chains is defective, the haemoglobin's ability to bind to (carry) the oxygen/carbon dioxide is hindered. The two kind of protein chains are: Beta globin chain = needs one gene per parent, and Alpha globin chain = needs two genes per parent. In Hemoglobin H disease the Alpha globin chains are affected, namely, three genes (one from one parent and 2 from the other parent) are defective (missing). That results in insufficiant oxygenation of the tissues, - anaemia -, ranging from moderate to severe. More information could be found at related links.


Two alpha chains and two gamma chains make up the protein globin part of?

Two alpha chains and two gamma chains make up the protein globin part of fetal hemoglobin (HbF). This type of hemoglobin is predominant in fetuses and newborns, and has a higher affinity for oxygen than adult hemoglobin (HbA), allowing for efficient oxygen transfer across the placenta.


What are the function of chain banking?

what are the function of chain banking


Hemoglobin is an example of a protein with what type of structure?

Hemoglobin is an example of a protein with quaternary structure, which means it is comprised of multiple subunits. In the case of hemoglobin, it consists of four subunits - two alpha and two beta globin chains.


What is the molecular weight of the alpha 1 chain in type V collagen?

The alpha 1 chain in type V collagen has a molecular weight of approximately 140 kDa.