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The major difference between the trade routes controlled by Italian city-states, such as Venice and Genoa, and other trade routes lies in their strategic geographic locations and economic focus. Italian city-states dominated Mediterranean trade, connecting Europe with the East and facilitating the exchange of luxury goods like spices and silk. In contrast, other trade routes, such as those in Northern Europe or overland routes like the Silk Road, were more focused on bulk goods and had less direct access to the lucrative East-West trade. This allowed Italian city-states to develop advanced banking and trade practices, enhancing their economic power during the Renaissance.

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