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The conquistadors primarily took routes through Central and South America, following established indigenous trails and waterways. Hernán Cortés traveled from Cuba to the Aztec Empire in present-day Mexico, while Francisco Pizarro journeyed from Panama to conquer the Inca Empire in Peru. Many expeditions also navigated through the Caribbean, utilizing coastal ports as launching points for inland exploration. These routes facilitated the conquest of vast territories and the establishment of Spanish colonial rule.

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