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Theory put forth by two French radiobiologists; Bergonie and Tribondeau in 1906. The theory offers a prediction about the relative sensitivity of two different types of cells or tissues to radiation. The so-called Law of Bergonie and Tribondeau concluded that cells tend to be radiosensitive if they have three properties:
(1) Cells have a high division (Mitotic) rate.
(2) Cells have a long dividing future.
(3) Cells are of an unspecialized type
Wiki User
∙ 13y ago
The law of Bergonie and Tribondeau states that the sensitivity of tissues to radiation is influenced by their rate of proliferation and level of differentiation. Essentially, rapidly dividing and undifferentiated cells are more sensitive to radiation damage, while slowly dividing and differentiated cells are more resistant. This principle helps guide radiation therapy by targeting cancer cells that are more sensitive to radiation.
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