What animes are about eccentrics?

Answer 1

This is a pretty broad question, but just like American Cartoons, there are a lot of Anime and Manga that focus on an everyday protagonist who is surrounded by abnormal characters.

The best one to look for if you are into either shonen action or comedy would be "Katekyo Hitman Reborn!" or just "Reborn!". It's a series about a school boy who is searched out by the world's greatest hit-man and learns that he is to become the boss of one of the most sinister mafia families in Italy. It has a really zany cast of characters and shifts from comedy to action and fighting over time. Another good choice for this category would be "Hayate the Combat Butler", but that's geared at a more mature audience.

If you are into crime, drama, psychological thriller, or any of that more series stuff, I would highly recommend a series called "Monster". It relates to a Japanese doctor in Germany who saves the life of a little boy over an important official, but learns many years later that the boy has grown up and become a serial killer. He travels all across Europe and meets several interesting characters. They aren't eccentric in the sense of being humorous, but they have interesting quirks and are much more three dimensional than characters in most other works.

I hope that this is what you are looking for. There are more Anime than you can shake a stick at, so Wikipedia can be a great help to find more specific series if none of these perk your interest.