An alkylating agent is a compound that's capable to replace a hydrogen for an alkyl group to a specific place on a molecule. Alkylating agents attacks mostly on a nitrogen, oxygen or sulfur.
Common alkylating agents are: Methyl iodide(or other haloalkanes), dimethylsulfate and some carboxylic acid alkyl esters.
Cyanide
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Infectious agents are microorganisms that can cause disease in hosts. They include bacteria, viruses, fungi, parasites, and prions. These agents can invade and multiply within host organisms, leading to various infections and illnesses. Understanding these agents is crucial for disease prevention and treatment.
Prothombin
No
immunomodulators alkylating drugs alkylating agents nitrogen mustard
An alkylating agent is a compound that's capable to replace a hydrogen for an alkyl group to a specific place on a molecule. Alkylating agents attacks mostly on a nitrogen, oxygen or sulfur. Common alkylating agents are: Methyl iodide(or other haloalkanes), dimethylsulfate and some carboxylic acid alkyl esters.
Alkylating drugs kill cancer cells by directly attacking DNA, the genetic material of the genes. Cyclophosphamide is an alkylating drug.
žNitrogen mustards: such as mechlorethamine (nitrogen mustard), chlorambucil, Cyclophosphamide (Cytoxan), ifosfamide, and melphalanžžNitrosoureas:streptozocin, carmustine (BCNU), and lomustinežAlkyl sulfonates: busulfanžžTriazines: dacarbazine (DTIC) and temozolomide (Temodar)žžEthylenimines: thiotepa and altretamine (hexamethylmelamine)žThe platinum drugs (cisplatin, carboplatin, and oxalaplatin) are sometimes grouped with alkylating agents because they kill cells in a similar way.
Chemicals that can react with DNA include alkylating agents (e.g. EMS), intercalating agents (e.g. ethidium bromide), oxidative agents (e.g. hydrogen peroxide), and reactive oxygen species like hydroxyl radicals. These chemicals can lead to DNA damage such as base modifications, strand breaks, and crosslinks.
Nitrogen mustards, such as cyclophosphamide, are alkylating agents that bind DNA and cause cross-linking that prevents replication. This inhibits cell division, most specifically in rapidly dividing cells of cancer masses.
It causes DNA strands in cells to break and rearrange
Yes, nitrogen mustard vesicants are known to cause blistering. These compounds can damage the skin and mucous membranes, leading to severe blister formation upon contact. They act as alkylating agents, interfering with cellular processes and resulting in tissue injury. The severity of the blistering depends on the concentration and duration of exposure.
broadly classified into chemical and radiative mutagens.Chemical mutagens are classified as alkylating agents, cross-linking agents, and polycyclic aromatic hydrocarbons (PAHs). Alkylating agents act by adding molecular components to DNA bases, which alters the protein product. Cross-linking agents create covalent bonds with DNA bases, while PAHs are metabolized by the human body into other potentially mutagenic molecules.Radiation is another potent mutagen. For biologists, the most significant forms of radiation are light, heat, and ionizing radiation. Ionizing radiation can penetrate cells and create ions in the cell contents. These, in turn, can cause permanent alterations in DNA; that is, mutations. Ionizing radiation includes: x rays, gamma rays, and the subatomic particles-neutrons, electrons ("beta" particles), and alpha particles (helium nuclei). Ionizing radiation alters the way two strands of DNA interact. This high energy radiation passes through cells and tissues, cutting up any DNA in its path. It can rearrange entire sections of the chromosomes, altering relatively long stretches of DNA. UV radiation causes covalent bonds to form between neighboring thymine bases in the DNA, so altering the DNA product at that location..
Chemotherapy drugs, often referred to as cytotoxic agents, can include a variety of medications such as alkylating agents (e.g., cyclophosphamide), antimetabolites (e.g., methotrexate), plant alkaloids (e.g., paclitaxel), and anthracyclines (e.g., doxorubicin). The specific drugs used depend on the type of cancer being treated and the patient's individual treatment plan. These drugs work by targeting rapidly dividing cancer cells, but they can also affect normal cells, leading to side effects. Combination therapies are common to enhance effectiveness and reduce the risk of resistance.
Oil refining is the process of distilling oil and then further reforming, catalytic cracking, hydrofining, blending, and sometimes coking, hydrocracking, alkylating various fractions of the distilled oil.
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