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Yes it can.

In fact, this is specifically the target of Type 1 Fimbriae. Many pathogenic Enterobacteriaceae posses this kind of Fimbriae as a virulence factor.

These Fimbriae contain receptor domains similar to the MBL (Mannose Binding Lectin) present in blood plasma.

The difference is that the human MBL recognizes the pathogen's Mannose residues and can initiate the MB-Lectin pathway, activating the complement cascade. This leads to pathogen opsonization.

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