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Mutations can pose varying levels of danger to the cell. The reason they can be bad is because DNA produces mRNA, which is used to produce proteins. A mutation is comparable to a typo in an instruction manual; how harmful it is depends on which letter is changed in which word. Like, if the instruction book is for how to make a sandwich, and the typo turns "the" into "teh," it doesn't really affect the meaning. On the other hand, if it turns "bread" into "beard," then you have a problem.

Same with mutations: they impede function by changing the protein-building instructions and causing the cell to produce a messed-up protein. Sometimes the protein is close enough in structure to the original and the cell can just roll with it,, but occasionally it changes a protein so drastically the cell can't use it at all. The danger with that depends on what a protein does. If it has the same function as a bunch of others or does something the cell an live without, it may not be dangerous. But if it happens to be the only protein a cell makes that does something, and the cell cannot live or function properly without it... then there's a pretty big problem.

Cells deal with mutations by, first of all, trying their best to keep them from happening. Back to the instruction book example: We assume this book was written on a computer with a word processing program, and, like most word processing programs, it has spell check. The "the-teh" typo would have been caught and likely changed to "the", while the "bread-beard" one would not have. So the typo that most changed the meaning of the manual would have slipped by the spell checker. And that seems to be what happens with mutations. For example, some of the most dangerous diseases come from a one-base change in the DNA code. For some reason, DNA's built-in spell checker doesn't catch it, although it will catch almost anything else. Odd thing is, though, that if any other nucleotide in the code for the protein that ends up messed up and causes the disease had been changed, the protein would have been fine and the disease wouldn't happen.

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